• Ada - Ada is a clean, minimalist little Twitter app that doesn’t hog up your desktop or distract you with a million features. See and send tweets and replies. Ada is built on Adobe Air and runs on both PCs and MACs.
  • AlertThingy - AlertThingy v2 brings the very latest updates from your favourite social networks direct to your desktop. Plus send Tweets, update your Facebook status, upload photos to Flickr, post to Tumblr and more. With v2 AlertThingy makes it faster and easier to manage the online you. Plus you get the coolest looking RSS reader on the interweb.
  • Airmailr - A full-featured Mac OS X dashboard widget for Twitter
  • BigTweet - BigTweet installs as a bookmarklet and allows you to post to Twitter from any web page. Choose a classic 140 character update, or a 240 character tweet. Insert special Unicode characters and shorten URLs with the Bit.ly API right from the bookmarklet window. Automatically capture the current page title, URL and any highlighted text. No registration is required - only Twitter login credentials are needed.
  • Blogo - A weblog editor which is also a full-featured Twitter client integrated with Twitpic, tinyURL, tweetburner and Ping.fm.
  • Celly. OS X. The original Twittergotchi as a downloadable app by Chris Messina
  • Chirp v.5. OS X. Dashboard Widget for Twitter, FriendFeed, Identi.ca, and Pownce by Warm Chocolate.
  • Chitter. OS X. Plug-in for iChat by ROFL Software
  • EventBox. OS X. Social network aggregator with full support for Twitter (searching, etc).
  • feedalizr - A free deskptop application that allows you to view, rate and comment on what your friends are sharing online. Tweet, upload pics to Flickr, update your Facebook status, keep up to date with your friends’ Google Reader, Digg, Tumblr, YouTube and Last.fm posts on Friendfeed. Use unique filters to reduce the noise. Duplications are filtered out. — by MIH SWAT
  • Friendbar- A Firefox toolbar that is the best way to follow Twitter & Facebook updates, and post to Twitter and Facebook
  • iChat Status to Twitter. Applescript that pushes your iChat status, including iTunes current song by WT Leroux
  • iTunes to Twitter. Applescript that pushes out your iTunes current song by WT Leroux
  • MoodBlast. Updates Twitter (and Facebook, Jaiku, Tumblr, Yappd, iChat, Adium, Skype) from a hotkey with extensive replacement strings.
  • NatsuLion - NatsuLion is a simple native Twitter client for Mac OSX with ability to view only @replies.
  • Nambu - Free desktop application that combines Twitter, FriendFeed, Twitter Search and tr.im URL shortening together into a great streamlined experience.
  • P3:PeraPeraPrv for Mac - P3: PeraPeraPrv for Mac is fully functional twitter client based on Java. P3 supports full-keyboard based operation, filter view to tracking with @id’s and keyword, quick-appearance changing, English/Japanese/Chinese interface and many features.
  • PhotoTwitter. This application allows you to take a Snapshot using your iSight and post the photo and your text on Twitter.
  • Pwytter - The free open source Twitter client written in Python now packaged as an App
  • RAILhead Design. Wiki page. UPDATED TO v1.3.2 on 02-23-2007.
  • Robin. OS X Dashboard Widget by SimplyExcited.
  • Scalaris - OS X. Built as minimal and unintrusive as possible. Relies on Growl.
  • TikiTwit . Updates your Twitter status when you change your iChat status.
  • Tototl 1.4 - An opensource and lightweight Twitter Client for Mac OSX in Cocoa
  • Twidget. OS X. Twitter Dashboard by Aquabox
  • Twitgit. OS X. Dashboard Widget by Ben Ward (See also Wiki Page)
  • Twitter from TextMate - A simple little script that allows you to tweet from TextMate with a GUI Dialog popup.
  • Twittereze SIMBL extension for Twitterific by Sören Kuklau
  • Twitterlex. Dashboard Widget by Brett Taylor
  • Twitteromatic. OS X. Send out current weather, iTunes track, secret word of the day, this day in history, uptime and current IP.twitter zone
  • TwitterPod. A Twitter app
  • TwitterPost. OS X. Desktop app by Maury McCown
  • Twitterrific. OS X. Desktop app by Iconfactory (See also Wiki page)
  • Twitter Studio. OS X Desktop app by BlueCrestStudios
  • Twittia Twitter-client for OS X by Jeena Paradies
  • Twoot - An ad-free open source minimalistic customizable twitter client for those who know HTML and CSS. Appified with Fluid.
  • Visionary Saver. A Mac OS X screen saver for Twittervision, Twittervision 3D, Flickrvision, and various others.
  • Twitterlights MAC app that allows for one click tweeting and content saving (and much more) all free!
  • Twitminal Terminal app with growl notifications, very lightweight, free kind of cool .